- Title
- Confocal microscopy, dermoscopy, and histopathology features of atypical intraepidermal melanocytic proliferations associated with evolution to melanoma in situ
- Creator
- Rocha, Lilian K. F. L.; Vilain, Ricardo E.; Scolyer, Richard A.; Lo, Serigne N.; Drummond, Martin; Star, Phoebe; Fogarty, Gerald B.; Hong, Angela M.; Guitera, Pascale
- Relation
- International Journal of Dermatology Vol. 61, Issue 2, p. 167-174
- Publisher Link
- http://dx.doi.org/10.1111/ijd.15815
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2022
- Description
- Background: Atypical intraepidermal melanocytic proliferations (AIMP) is a descriptive term sometimes applied to biopsies that do not fulfill diagnostic criteria of melanoma. They are common on sun-damaged skin, but their definition and management are controversial. Objective: To describe dermoscopic (DS), reflectance confocal microscopic (RCM) and histopathological features of AIMP and identify features associated with subsequent melanoma in situ (MIS). Methods: A retrospective analysis of AIMP lesions correlated with patient outcome at two melanoma tertiary centers between 2005 and 2015. Results: Thirty-four patients were included. Nine (26%) patients had MIS in subsequent biopsies. Predictors of later MIS were target-like pattern (OR:12.0 [CI: 1.23, 117.41]; P = 0.032) and high-density vascular network (OR:12 [CI: 1.23–117.41], P: 0.032) on DS, and presence of dendritic cells touching each other (OR:9.1 [CI: 1.54, 54.59], P = 0.014) on RCM. Clinical predictors of worse outcome included a previous history of MIS at the same site. Radiotherapy for AIMP had a high failure rate (all patients presented with recurrent disease, three as AIMP and two as MIS). Conclusions: Considering that most cases in this series received non-surgical treatment at baseline, we recommend close monitoring for lesions with target-like pattern and density vascular network on DS and treatment for lesions with progression of atypia and/or with “confluent” dendritic cells on RCM. Although the number of patients in this series is very low, early surgery is recommended for MIS cases that recur as AIMP.
- Subject
- atypical intraepidermal melanocytic proliferations (AIMP); melanoma; confocal; dermoscopy; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1453981
- Identifier
- uon:44783
- Identifier
- ISSN:0011-9059
- Language
- eng
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